6-Chloro-3-nitro-8-(phenylthio)-2-[(phenylthio)methyl] imidazo[1,2-a]pyridine
نویسندگان
چکیده
As part of our ongoing antikinetoplastid structure–activity relationship study focused on positions 2 and 8 the 3-nitroimidazo[1,2-a]pyridine scaffold, we were able to introduce a phenylthioether moiety at both position in one step. Using previously reported synthetic route developed laboratory, obtained 6-chloro-3-nitro-8-(phenylthio)-2-[(phenylthio)methyl]imidazo[1,2-a]pyridine 74% yield. The vitro cell viability this compound was assessed HepG2 line, its activity evaluated against promastigote form L. donovani, axenic amastigote infantum trypomastigote blood stream T. b. brucei. It showed low solubility culture medium (CC50 > 7.8 µM), associated with weak donovani (EC50 = 8.8 9.7 µM) brucei 12.8 µM).
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ژورنال
عنوان ژورنال: Molbank
سال: 2023
ISSN: ['1422-8599']
DOI: https://doi.org/10.3390/m1613